Statistical significance

Statistical significance for genome-wide studies.

We cover the following parts:

  • Abstract
  • Example 1, differentially expressed genes
  • Table 1
  • What is a p-value?
  • What is the FDR?
  • Derivation that p-values are uniformly distributed under the null hypothesis
  • Figure 1
  • FDR estimation
  • Figure 2
  • What is a q-value?
Last modified May 30, 2023: update Gaussian processes (ff6a6c2)